Gus and Jeanette will be presenting
Genome-wide screens Yamamoto, S, et al A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell. 2014 Sep 25;159(1):200-214. doi: 10.1016/j.cell.2014.09.002.
Review: Xiong, X, et al CRISPR/Cas9 for Human Genome Engineering and Disease Research. Annu Rev Genomics Hum Genet. 2016 Aug 31;17:131-54. doi: 10.1146/annurev-genom-083115-022258. Epub 2016 May 23.
Sheida and Erin will be presenting the following papers:
Pastuzyn ED, et al The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. Cell. 2018 Jan 11;172(1-2):275-288.e18. doi: 10.1016/j.cell.2017.12.024.
*Overview of back to back papers in Cell: http://www.cell.com/cell/fulltext/S0092-8674(17)31509-X
*Popular Press Article (A must read): https://www.theatlantic.com/science/archive/2018/01/brain-cells-can-share-information-using-agene-that-came-from-viruses/550403/
David Lee, Oliver Redfern & Christine Orengo Predicting protein function from sequence and structure Nature Reviews Molecular Cell Biology 8, 995-1005 (December 2007) | doi:10.1038/nrm2281
Ontologies: Scientific Data Sharing Made Easy Nicole Washington & Suzanna Lewis (2008) https://www.nature.com/scitable/topicpage/ontologies-scientific-data-sharing-made-easy-77972/
Olivia and Lucas will be presenting these papers:
Margolis SR1, Wilson SC2, Vance RE3.
Evolutionary Origins of cGAS-STING Signaling.
Trends Immunol. 2017 Oct;38(10):733-743. doi: 10.1016/j.it.2017.03.004. Epub 2017 Apr 14.
Review:Phylogeny for the faint of heart: a tutorial. Baldauf SL.
Trends Genet. 2003 Jun;19(6):345-51. PMID: 12801728
Carissa Waldo and Tanner Zocher will present the following papers:
Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies. Khan TN, Khan K, Sadeghpour A, Reynolds H, Perilla Y, McDonald MT, Gallentine WB, Baig SM;Task Force for Neonatal Genomics, Davis EE, Katsanis N.Am J Hum Genet. 2019 Jan 3;104(1):94-111. doi: 10.1016/j.ajhg.2018.11.017.
(Choose the best ideas from Review papers. you don’t have to use everything, most important is to tell a story) Note to speakers:Talk about next-gen sequencing (ie what is it and how it works), the history, and then how model organisms are facilitating disease diagnosis.You need to make a story to lead into the primary paper above.
Next-generation sequencing: impact of exome sequencing in characterizing Mendelian disorders. Rabbani B, Mahdieh N, Hosomichi K, Nakaoka H, Inoue I.
J Hum Genet. 2012 Oct;57(10):621-32. doi: 10.1038/jhg.2012.91. Epub 2012 Jul 26. Review. PMID: 22832387
Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research.
Wangler MF,Yamamoto S, Chao HT, Posey JE,Westerfield M, Postlethwait J; Members of the Undiagnosed Diseases Network (UDN), Hieter P, Boycott KM, Campeau PM, Bellen HJ.
Genetics. 2017 Sep;207(1):9-27. doi: 10.1534/genetics.117.203067. Review.
I'm excited to meet all of you!
Please email me your top 3 Genes/Diseases of your choosing before January 23rd.
I will be vetting your projects and will confirm with you your final choice via email
Please note: Bring laptops to class every tuesday and thursday.
We will be using DIGITAL rubrics to evaluate presentations.