Rohan and Joely will be presenting the following papers:
Pastuzyn ED, et al., The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. Cell. 2018 Jan 11;172(1-2):275-288.e18. doi: 10.1016/j.cell.2017.12.024. David Lee, Oliver Redfern & Christine Orengo, Predicting protein function from sequence and structure Nature Reviews Molecular Cell Biology 8, 995-1005 (December 2007) | doi:10.1038/nrm2281 Overview of back to back papers in Cell: http://www.cell.com/cell/fulltext/S0092-8674(17)31509-X Popular Press Article (A recommended read): https://www.theatlantic.com/science/archive/2018/01/brain-cells-can-share-informationusing-a-gene-that-came-from-viruses/550403/
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Sara and Rebecca will be presenting these papers:
Feb 8th: Phylogenomics Worobey M, Pekar J, Larsen BB, Nelson MI, Hill V, Joy JB, Rambaut A, Suchard MA, Wertheim JO, Lemey P. The emergence of SARS-CoV-2 in Europe and North America. Science. 2020 Oct 30;370(6516):564-570. doi: 10.1126/science.abc8169. Epub 2020 Sep 10. PMID: 32912998; PMCID: PMC7810038. Reviews: • Geoghegan JL, Holmes EC. The phylogenomics of evolving virus virulence. Nat Rev Genet. 2018 Dec;19(12):756-769. doi: 10.1038/ s41576-018-0055-5. PMID: 30305704; PMCID: PMC7096893. • Phylogeny for the faint of heart: a tutorial. Baldauf SL. Trends Genet. 2003 Jun;19(6):345-51.PMID: 12801728 **Nextstrain: https://www.fredhutch.org/en/research/diseases/coronavirus/understanding-nextstrain.html **Reuter’svisualization of the virus mutations: https://graphics.reuters.com/HEALTH-CORONAVIRUS/EVOLUTION/yxmpjqkdzvr/ Trevor Bedford’s website and data visualizations: https://bedford.io/ Kate and Zoe will be presenting the following papers:
Koblan LW, et al. In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice. Nature. 2021 Jan 6. doi: 10.1038/s41586-020-03086-7. Next-generation sequencing: impact of exome sequencing in characterizing Mendelian disorders. Rabbani B, et al, J Hum Genet. 2012 Oct;57(10):621-32. doi: 10.1038/jhg.2012.91. Epub 2012 Jul 26. Review. PMID: 22832387 Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research. Wangler MF, Y et al., Genetics. 2017 Sep;207(1):9-27. doi: 10.1534/genetics.117.203067. Review. Progeria video: https://www.youtube.com/watch?v=GO306dK8m8c Please post questions for your classmates no later than NOON on Feb 1st to maintain your 5pts.Be prepared to ask this question or any question in class for another 5pts. |
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April 2024
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